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DNA structure

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Vicious Circles – how changes in the shape of DNA can drive cancer

The diploid human genome contains 23 pairs of chromosomes whose DNA encodes genes for life activities, such as cell division. Cancer corrupts those genes, making growth-promoting genes more active (oncogenes) or growth-inhibiting genes (tumor suppressors) less active. One of the most common genetic alterations causing... click to read more

  • Sihan Wu | Postdoctoral Research Fellow at Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA
  • Paul S. Mischel | Professor at Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA
Views 582
Reading time 3.5 min
published on Aug 17, 2020
DNA G-Quadruplexes: ‘knot’ that simple!

Known as the "molecule of life", DNA is found in every cell in our body, providing a set of instructions for the function and organization throughout our bodies. These instructions are encoded by only four structural variations, abbreviated to A, C, G and T. While... click to read more

  • Mateus Webba da Silva | Professor at School of Pharmacy and Pharmaceutical Sciences, Biomedical Sciences Research Institute, Ulster University, Coleraine, UK
  • Scarlett Dvorkin | PhD Student at School of Pharmacy and Pharmaceutical Sciences, Biomedical Sciences Research Institute, Ulster University, Coleraine, UK
Views 2142
Reading time 3.5 min
published on Feb 20, 2019