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As Online, Open Access, and Outreach Journal, we promote the democratization of scientific literature to foster dialogues and interest over the most recent scientific advances. Discover our mission.

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Obesity increases cancer risk, yet obese patients often respond better to cancer immunotherapy. In our study, we uncovered why: high estrogen levels, especially in obese men, boost the immune response triggered by immunotherapy. This reveals a key role for estrogens in improving treatment effectiveness.

in Evolution & Behaviour
Cicada emergence alters forest food webs
 Jan 31, 2025 | 3.5 min read by Martha Weiss , John Lill
in Evolution & Behaviour
Size does not matter: direct estimations of mutation rates in baleen whales
 Jan 29, 2025 | 4 min read by Marcos Suárez-Menéndez
in Earth & Space
Discovery of the first radiation belt beyond the Solar System
 Jan 27, 2025 | 3.5 min read by Juan Bautista Climent Oliver
in Earth & Space
One million (paper) satellites
 Jan 24, 2025 | 3 min read by Ewan Wright , Andrew Falle
in Evolution & Behaviour
The Claws and the Spear: New Evidence of Neanderthal-Cave Lion Interactions
 Jan 22, 2025 | 3.5 min read by Gabriele Russo

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How obesity can improve the efficacy of cancer treatment: role of the sex hormone estrogens.

Obesity increases cancer risk, yet obese patients often respond better to cancer immunotherapy. In our study, we uncovered why: high estrogen levels, especially in obese men, boost the immune response triggered by immunotherapy. This reveals a key role for estrogens in improving treatment effectiveness.

Dec 3, 2025 | 3.5 min read