In many types of heart disease, cardiac tissue exhibits excessive extracellular matrix deposition, and fibrosis. This increases the stiffness of the heart, limiting its pumping capacity. By administering specially designed immune cells, which remove the cells responsible for fibrosis, we are able to diminish the quantity of fibrosis greatly.

High mountains around the globe have long been thought to represent pristine ecosystems that have been reshaped by humans quite late in the earth's history. The recent discovery of a 47-31 thousand-year-old residential site at 3,500 m in the Ethiopian Highlands contradicts this view and highlights the early expansion of Middle Stone Age hunter-gatherers into the cold and glaciated mountains.

Hidden from the eye, plant roots interact with a diverse community of microorganisms living around them. These interactions can have a considerable effect on the health and growth of the plant. Still, our knowledge of how plants modulate them is limited. This study looks at root-specific metabolites, showing some can affect the composition of root-microbiota.

Antimicrobial resistance is a survival strategy used by bacteria to disarm antimicrobials. In some cases, bacteria take advantage of proteins located on the surface of their body to pump out the molecules that would otherwise harm them. We discovered that a new family of these proteins can pump out polymer precursors. Therefore, they can be harnessed in the microbial production of such compounds.

We have discovered not only what happened to the people of an abandoned ancient Maya city, but the exact day that much of the population disappeared. The study was a collaboration between earth scientists, who took a core from a lake that sits just below the ruins of an ancient Maya city, and archaeologists who excavated the monuments and structures of the site.

Before footwear, calluses served as the primary protection for our feet. To understand how our species walks safely without shoes, we investigated foot skin biology in regularly barefoot and shod people in Western Kenya. Unlike shoes, calluses protect without trading off sensitivity or changing impact forces in walking, making them a remarkable example of evolutionary engineering.