Phosphorylation is a fundamental mechanism in eukaryotic cells that allows signals to propagate. Kinases orchestrate this process by phosphorylating proteins to modulate their activity. Our work reveals the architecture of the complex between two key players of the mitogen-activated protein kinase signaling pathway, p38α and MKK6, while also giving an idea of what happens when the two come together.

A fixed point is a point that does not move when subjected to a given transformation. Theorems guaranteeing the existence of such points have a wide application not only in mathematics, but also in economics or in Google's search engine. Such a new theorem has recently been discovered: every isometry has a fixed point when viewed in an extended space.

Epigenetic regulation consists in chemical modifications on the proteins that organize DNA. Here, we show how it increases gene copies and rearranges the MLL gene, which associates with infant, adult, and therapy-associated leukemia. These findings show how chemotherapy-induced MLL changes occur and provide a therapeutic way to prevent them.

The rich energy structure of ultracold molecules (at -459 °F or -273 °C),  gives rise to collisional dynamics where the state-of-the-art models are inadequate for describing collisional resonances. We have discovered a pronounced magnetically tuned resonance in collisions between two NaLi molecules, which enhances the chemical reaction rate by more than a factor of a hundred.

We discovered that the immune response to a common virus called Epstein-Barr virus may be linked to multiple sclerosis by cross-reacting with a protein in the body called alpha-crystallin B . People who reacted to this protein were more likely to develop the disease, and this finding is a step forward in our understanding of how this common virus may cause disease in some people.

While exploring the root cause of trees' gravity sensing, the Morita lab stumbled upon proteins called ‘LAZY’ and dissected their association with the starch-filled packets in roots to dissolve a long-standing dilemma – is gravity sensed in terms of the force that the heavy starch-filled packets exert on the cell content or is it their position that send signals dictating where the Earth is?