Nature has always been an interesting source of chemical diversity for the search of molecules of therapeutic interest. Here we showed how large plant extract libraries can be transformed into a chemical library. This library could then be efficiently used to isolate molecules of unreported bioactivity to advance our knowledge on disease treatments.

Patients with a diagnosis of breast cancer or lymphoma who received chemotherapy treatment might be at risk of long-term side effects. We evaluated the association between a type of chemotherapy, called anthracyclines, and the risk of developing heart failure in patients with cancer. In this study, patients treated with anthracycline were more likely to have heart failure compared to controls.